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Paper title T1, T2 and T2* relaxivity changes in brain white and gray matter in anorexic patients
Paper code P54
Authors
  1. José Boto Hôpitaux Universitaires de Genève Speaker
  2. Alice Regnaud Hôpitaux Universitaires de Genève
  3. Gkinis Georgios Hôpitaux Universitaires de Genève
  4. Tobias Kober Advanced Clinical Imaging Technology
  5. Karl-Olof Lövblad Hôpitaux Universitaire de Genève HUG
  6. François Lazeyras Hôpitaux Universitaires de Genève
  7. Nurten Ceren Askin Hôpitaux Universitaires de Genève
  8. Maria Isabel Vargas HUG Hôpitaux Universitaires Genève
Form of presentation Poster
Topics
  • SSNR-Neuroradiology
Abstract text AIM
Anorexic related morphological brain changes have been demonstrated in the literature. The aim of this study is to uncover further brain abnormalities in T1, T2 and T2* relation times of white and gray matter in anorexic patients.

METHODS
Subjects are 35 anorexic females (mean age, 25.7 years; range, 16.2-48.7 years) with BMI inferior to 18.5 kg/m2 (mean BMI, 14.4 kg/m2; range, 10.0-18.4 kg/m2) presenting consecutively for brain MR between August 2014 and February 2018. Controls include 15 healthy females (mean age, 27.7 years; range, 22.4-34.7 years; mean BMI, 21.0 kg/m2, range, 18.4-27.3 kg/m2). Automated brain segmentation will be performed on MP2RAGE MR images. The masks obtained will then be transferred to the specific T1, T2 and T2* mapping sequences in order to quantify the respective relaxation times of total brain and different brain structures in anorexics and controls.

RESULTS
Preliminary results based on hand drawn elipsoid shaped ROIs (regions of interest) in the white matter of the centrum semiovale revealed significantly lower T1 relaxation times in the anorexic group compared to age and sex matched controls (p=0.028). T2 and T2* relaxation times did not show a significant difference between the two groups. We expect that the application of the automated segmentation method will add additional accuracy and allow differences in the relaxation times of whole brain, and different brain structures and regions between anorexics and controls to become more apparent.

CONCLUSIONS
Preliminary results show significantly lower T1 relaxation times in brain white matter of anorexics compared to normal controls, possibly reflecting starvation driven myelin depletion. We expect that this first attempt at performing T1, T2 and T2* brain mapping in anorexics might open the door to possible treatment options and motivate further longitudinal studies to confirm the resolution of these abnormalities.