Paper title | Intracranial Meningeal Hemangiopericytomas: An Analysis of factors affecting outcome from multimodality treatment of 39 Cases. |
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Paper code | P01 |
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Form of presentation | Poster |
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Abstract text |
Aim: To retrospectively evaluate outcome of patients with intracranial menin-geal hemangiopericytomas (MHPCs) & to analyse various factors for recur-rence and survival in these patients. Materials & Methods: We retrospectively reviewed the clinical data of 39 patients undergoing micro-surgical resection for MHPCs at our institute from 2009 to 2015. Results: GTE was achieved in 27 (69.2%) patients while 12 (30.8%) underwent STE. Twenty five patients received radiotherapy (Conventional RT-15; GKT-10). Twenty one patients had low grade while 18 had anaplastic variant. Twenty pa-tients (51.3%) developed recurrences. Average recurrence free survival (RFS) was 56 months (range:12-180 months). Eight patients (20.5%) died during study period. The average overall survival (OS) was 77.2 months (range: 36-192 months). Two patients (5.1%) developed systemic metastases during fol-lowup. Patient age was not found to affect RF or OS. GTE was associated with prolonged RFS & OS but the impact was not statistically significant (p values-0.160 & 0.414 respectively). Low tumor grade was associated with statistically significant longer RFS as well as OS (p values-0.049 & 0.013 respectively). Addition of adjuvant RT was associated with statistically significant prolonga-tion of RFS (p value-0.016) however, it was not associated with statistically significant overall survival benefits (p value-0.758). Conclusions: Our study suggests that extent of excision, low tumor grade & addition of adju-vant RT have a positive impact on both RFS & OS, however, low grade & ad-juvant RT were the only factors associated with statistically significant prolon-gation of RFS & only tumor grade was associated with statistically significant overall survival benefits. |